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M9490063.TXT
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1994-09-03
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Document 0063
DOCN M9490063
TI Necrotizing ulcerative periodontitis: a marker for immune deterioration
and a predictor for the diagnosis of AIDS.
DT 9411
AU Glick M; Muzyka BC; Salkin LM; Lurie D; University of Pennsylvania
School of Dental Medicine,; Philadelphia.
SO J Periodontol. 1994 May;65(5):393-7. Unique Identifier : AIDSLINE
MED/94322163
AB A multitude of oral lesions have been described in individuals infected
with the human immunodeficiency virus (HIV). Few studies have attempted
to correlate specific oral findings with immune status and HIV disease
progression in the population reflecting the demographic profile of this
epidemic. A prospective study was conducted among 700 ambulatory
HIV-infected individuals seeking dental care between July 1, 1988 and
June 30, 1992. Patients entered the study when they first applied for
care and were followed at regular intervals unless death occurred before
the conclusion of the study. The prevalence rate of necrotizing
ulcerative periodontitis (NUP) was calculated for the entire population
and specific to race, gender, and HIV transmission category. Survival
analysis was used to estimate the cumulative probability of death within
24 months of a NUP diagnosis. The association between NUP diagnosis and
CD4+ cell count below 200 cells/mm3 was also investigated, and it was
found that HIV-infected individuals presenting with a diagnosis of NUP
were 20.8 times as likely to have a CD4+ cell count below 200 cells/mm3
compared to HIV-infected individuals presenting without NUP. The
prevalence of NUP was 6.3%. The lesion was significantly more common
among men having sex with men (MSM), 8.4%, compared with non-MSM males,
1.8%. No racial difference was noted. The mean CD4+ cell count for
patients with NUP was 51.8 cells/mm3 (SD +/- 71.2) while the median CD4+
cell count was 32.0 cells/mm3. The predictive value of a CD4+ cell count
below 200 cells/mm3 in patients with this lesion was 95.1%. A cumulative
probability of death within 24 months of a NUP diagnosis was
72.9%.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Adult Female Gingivitis, Necrotizing Ulcerative/ETHNOLOGY/*IMMUNOLOGY
Human HIV Infections/COMPLICATIONS/*DIAGNOSIS Leukocyte Count Life
Tables Male Periodontitis/ETHNOLOGY/*IMMUNOLOGY Prognosis
Prospective Studies T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).